Bio

Dr. Bandyopadhyay has expertise in three-dimensional (3D) microfluidic systems, integrated with bioprinting technology, serve as advanced artificial biomicroenvironments that allow for the study and functional characterization of tissue remodeling in vitro. These systems overcome the limitations of traditional 2D cultures by providing a more physiologically relevant setting with precise control over key microenvironmental factors. The Key Features and Mechanisms he is studying include:

1) Biomimicry: Microfluidic platforms using hydrogels and other biomaterials to
create 3D scaffolds that mimic the native extracellular matrix (ECM) architecture
and mechanical properties.

2) Dynamic Flow and Gradients: Continuous perfusion within microchannels simulates physiological fluid flows (e.g., blood flow,
interstitial flow), enabling efficient nutrient/oxygen transport, waste removal, and the establishment of stable molecular and chemical gradients (e.g., growth factors, oxygen).

3) Functional Characterization: These platforms allow us to non- destructively monitor and characterize functional changes related to tissue remodeling in real-time. For example: Cell Behavior, Mechanical and Physiological Responses and Integration with 3D Bioprinting for creating more complex, multi-organ systems. 

Current Goals are to find applications of these include:

• Disease Modeling: Developing human-relevant 3D models of diseases, such as Kidney Stone, Calcification, CKD, COPD, TBI.
• Drug Screening: Providing high-throughput, cost-effective platforms for testing drug efficacy and toxicity in a human-relevant context, reducing reliance on animal models.
• Regenerative Medicine: Engineering functional tissues for potential therapeutic applications, such as vascularized kidney, or artificial tissues.

Representative Publications

Xu X, Qiu Y, Chen CY, Carton M, Campbell PMR, Chowdhury AM, Bandyopadhyay BC, Bentley WE, Smith BR, Sochol RD. 3D nanoprinting of PDMS microvessels with tailored tortuosity and microporosity via direct laser writing. Lab Chip. 2025 Apr 8;25(8):1947-1958. PMID: 40104860

Awuah Boadi E, Shin S, Gombedza FC and Bandyopadhyay BC*, Differential biomolecular recognition by synthetic vs. biologically derived components in stone-forming process using 3D microfluidics, Journal of Material Chemistry B, 2021 Dec 22;10(1):34-46. Journal cover 07 January 2022, Issue 1, Page 1-134.

Awuah Boadi E, Shin S, Bandyopadhyay BC*, Tannic acid attenuates vascular calcification-induced proximal tubular cells damage through paracrine signaling. Biomed Pharmacother. 2021 Aug;140:111762. PMID: 34126317

Awuah Boadi E, Deems N, Raub, CB; Bandyopadhyay BC, Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution. Crystal Growth & Design (ACS), 2019, 19(11) 6636-6648. PMID: 31749663.

Gombedza FC, Evans S, Shin S, Awuah Boadi E, Zhang Q, Nie Z and Bandyopadhyay BC. Melamine promotes calcium crystal formation in three- dimensional microfluidic device. Scientific Reports (Nature), 2019 Jan 29;9(1):875. PMID: 30696888.

Wei Z, Amponsah PK, Al-Shatti M, Nie Z, Bandyopadhyay BC. Engineering of polarized tubular structures in a microfluidic device to study calcium phosphate stone formation. Lab Chip. 2012 Oct 21;12(20):4037-40. PMID: 22960772

 

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