Dr. Raub’s research goal is to determine microscale mechanisms of tissue injury, remodeling, and repair, with insights that lead to novel diagnostic and therapeutic strategies. To achieve this objective, Dr. Raub’s laboratory is designed to merge tissue engineering, biomedical optics, and microfluidics to noninvasively capture cell and matrix dynamics in 3-D, and relate microscale features to macroscale tissue mechanics. Using similar approaches in the past, Dr. Raub has analyzed the influence of extracellular matrix microstructure on bulk mechanical properties of engineered tissue, pulmonary airways following epithelial injury, and articular cartilage during knee joint degeneration and surgical repair. This work occurred during his doctoral studies at the University of California, Irvine, from 2004-2009, and his postdoctoral work at the University of California, San Diego, from 2009-2013. From 2013-2014, Dr. Raub pursued a capstone postdoctoral experience at the Keck School of Medicine, University of Southern California, developing microfluidic assays for the detection of cancer mutations. Moving forward, the unifying theme of Dr. Raub’s research will be noninvasive assessment of and control over cell and matrix dynamics to inhibit pathologic and guide therapeutic remodeling of collagen-rich tissues.
Raub CB, Hsu SC, Chan EF, Chen AC, Truncale KG, Semler EJ, Chnari E, and RL Sah. Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer. Osteoarthritis and Cartilage. 21(6):860-8, 2013.
Stender ME, Raub CB, Yamauchi K, Shirazi R, Vena P, Sah RL, Hazelwood SJ, and SM Klisch. TGF-β1 and IGF-1 modulate articular cartilage collagen fiber modulus: continuous anisotropic fiber distribution FEA using qPLM, biochemical assay, and mechanical test data. Journal of Biomechanics. 12(6):1073-88, 2013.
Raub CB, Putnam AJ, Tromberg BJ, and SC George. Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy. Acta Biomaterialia. 6(12):4657-65, 2010.